Function Team Spotlight

Hygienic Process


An industrial process that by design, materials of construction, operation, and further processing provide for the maintenance of cleanliness so that intermediate or end products produced by these systems will not adversely affect human or animal health.



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PIP has chosen the term “hygienic”, but different industries use other terms for a similar purpose: Clean / Cleanable, Sanitary (excludes waste-water sanitation processes), Dairy / Dairy service, Sterile / Sterilized, Aseptic, Purification / Purified, Wash / Washable, Rinse / Rinseable, Current Good Manufacturing Practices (cGMP), Clean Design, Stability, Microbiologically Stable



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The Mission of Process Industry Practices is to collaborate to produce a library of engineering Practices encompassing globally relevant guidance and technical criteria within a program that provides opportunity for professional education and leadership development.

Therefore, the objective of the Hygienic Process Function Team is to develop and maintain Standards, Practices and Specifications for use in design and construction by leveraging the knowledge of technical experts and Best Engineering Practice Guidance Publications across these industries. 

The Hygienic Process Function Team is a uniquely broad team since hygienic practices cover the specific needs of “clean” requirements across the spectrum of current PIP Practices from Static/Rotating Equipment to Clean Room Insulation Systems

Most of the guidance documents and CODEs that “govern” the above processes merely set the minimum expectation of the end result or final product.  These governance documents DO NOT detail construction methods or specifications.



Examples of Hygienic Processes:

  • Hygienic Engineering Design
  • Biofuels
  • Electronics / Micro-electronics (silicone wafers, semi-conductor crystal growth, etc.)
  • Filter manufacturing
  • Consumer Goods (makeup, shampoo, soap, deodorant, etc.)
  • Food & Beverage
  • Fermentation
  • Eyecare products (drops, contact solution, cleaners, etc.)
  • Diagnostic laboratory kits & supplies
  • Pet Medicine, Prescription Medicine
  • Over the Counter Drugs
  • Pharmaceuticals (pills, capsules, inhalants, injectables, etc.)
  • Sterile Pharmaceuticals
  • Microbiological Processing
  • Biopharmaceuticals (cell culture, incubation, filtration)
  • Bulk Active Pharmaceutical Ingredients
  • Ingredients (excipients) for food, beverage
  • Clean in Place skids/systems
  • Sterilize in Place skids/systems
  • Purified Water (PW) and Water for Injection (WFI) generation, storage, and distribution
  • Cosmetics 
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Currently published Hygienic Process Practices include:

Copper Hygienic Piping Material Specification
PVDF Hygienic Piping Material Specification
316/316L Stainless Steel Hygienic Piping Material Specifications (9 Practices)
Instrumentation, Supports, Coatings and Insulation for CGMP Areas (4 Practices)
Hygienic Valve Descriptions (9 Practices)
Administrative Procedures for Hygienic Practices (2 Practices)